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June 2026
Value Estimates for Innovative Lipid-Lowering Therapeutics in ASCVD
Substantial health system and societal value remains for further reductions in cardiovascular events and mortality
In this Center for Pharmacoeconomics (CPE) Exclusive, we compare the impacts of an innovative lipid-lowering therapy used as an adjunct to statin therapy to statin therapy alone across a range of cost-effectiveness frameworks and assumptions.
Purpose of Report: Reducing cardiovascular events such as heart attacks and stroke can offer substantial value to patients, the health system, and society. Even considering the effectiveness of statins in reducing these events, unmet need exists to address suboptimal cholesterol levels and the residual risk of cardiovascular events. In this report, we evaluate some of the quantifiable health system and societal impacts of innovative lipid-lowering therapies that may further reduce these cardiovascular events.
Summary of Findings: An innovative lipid-lowering therapy that further reduces major adverse cardiovascular events by 20-30% could produce a lifetime societal benefit in the range of $79,000-$122,000 per person treated and a value-informed price in the range of $5,000-$21,000 per year at a cost-effectiveness threshold recently suggested by the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. These estimates may be conservative.
Key Considerations: The estimates are sensitive to a number of factors, including the model structure, time horizon, perspective, population, effectiveness and safety of the therapy, rates of events under standard therapy, and the cost-effectiveness threshold. Different plausible assumptions would generate different plausible estimates.
Interpreting the Findings: Read the report to see how the estimates vary by the effectiveness of the treatment, the cost-effectiveness framework used, and the cost-effectiveness threshold assumed. We do not provide these estimates to suggest a price for an innovative therapeutic, but rather to estimate some of the quantifiable health system and societal value, identify key drivers of health system and societal efficiency, suggest “novel” value elements that may influence the value proposition, and provide a reference point for how a product might perform under different cost-effectiveness analysis frameworks and assumptions. This may be useful to companies as they are thinking about evidence generation.
To discuss a specific innovative therapeutic in ASCVD with the Leerink Center for Pharmacoeconomics, please contact your Leerink representative.
Read our full report for more details and discussion.
Value Estimates for Innovative Lipid-Lowering Therapeutics in ASCVD
Click here to read the full report.
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The Leerink Center for Pharmacoeconomics is a division of MEDACorp and an affiliate of Leerink Partners
Leerink Center for Pharmacoeconomics
– Melanie Whittington, PhD, Managing Director, Head of the Center for Pharmacoeconomics
Disclosures
The Center for Pharmacoeconomics (“CPE”) is a division of MEDACorp LLC (“MEDACorp”). CPE is committed to advancing the understanding and evaluating the economic and societal benefits of healthcare treatments in the United States. Through its thought leadership, evaluations, and advisory services, CPE supports decisions intended to improve societal outcomes. MEDACorp, an affiliate of Leerink Partners LLC (“Leerink Partners”), maintains a global network of independent healthcare professionals providing industry and market insights to Leerink Partners and its clients. The information provided by the Center for Pharmacoeconomics is intended for the sole use of the recipient, is for informational purposes only, and does not constitute investment or other advice or a recommendation or offer to buy or sell any security, product, or service. The information has been obtained from sources that we believe reliable, but we do not represent that it is accurate or complete and it should not be relied upon as such. All information is subject to change without notice, and any opinions and information contained herein are as of the date of this material, and MEDACorp does not undertake any obligation to update them. This document may not be reproduced, edited, or circulated without the express written consent of MEDACorp.
© 2026 MEDACorp LLC. All Rights Reserved.
Disclosures
The Center for Pharmacoeconomics (“CPE”) is a division of MEDACorp LLC (“MEDACorp”). CPE is committed to advancing the understanding and evaluating the economic and societal benefits of healthcare treatments in the United States. Through its thought leadership, evaluations, and advisory services, CPE supports decisions intended to improve societal outcomes. MEDACorp, an affiliate of Leerink Partners LLC (“Leerink Partners”), maintains a global network of independent healthcare professionals providing industry and market insights to Leerink Partners and its clients. The information provided by the Center for Pharmacoeconomics is intended for the sole use of the recipient, is for informational purposes only, and does not constitute investment or other advice or a recommendation or offer to buy or sell any security, product, or service. The information has been obtained from sources that we believe reliable, but we do not represent that it is accurate or complete and it should not be relied upon as such. All information is subject to change without notice, and any opinions and information contained herein are as of the date of this material, and MEDACorp does not undertake any obligation to update them. This document may not be reproduced, edited, or circulated without the express written consent of MEDACorp.
© 2026 MEDACorp LLC. All Rights Reserved.
Disclosures
The Center for Pharmacoeconomics (“CPE”) is a division of MEDACorp LLC (“MEDACorp”). CPE is committed to advancing the understanding and evaluating the economic and societal benefits of healthcare treatments in the United States. Through its thought leadership, evaluations, and advisory services, CPE supports decisions intended to improve societal outcomes. MEDACorp, an affiliate of Leerink Partners LLC (“Leerink Partners”), maintains a global network of independent healthcare professionals providing industry and market insights to Leerink Partners and its clients. The information provided by the Center for Pharmacoeconomics is intended for the sole use of the recipient, is for informational purposes only, and does not constitute investment or other advice or a recommendation or offer to buy or sell any security, product, or service. The information has been obtained from sources that we believe reliable, but we do not represent that it is accurate or complete and it should not be relied upon as such. All information is subject to change without notice, and any opinions and information contained herein are as of the date of this material, and MEDACorp does not undertake any obligation to update them. This document may not be reproduced, edited, or circulated without the express written consent of MEDACorp.
© 2026 MEDACorp LLC. All Rights Reserved.
